Estrous Cycle Modulation Of Hippocampal Spine Dynamics, Dendritic Processing, And Spatial Coding
Gonadal hormones such as estradiol have a powerful effect on neuronal plasticity, particularly in the hippocampus, a region crucial for memory consolidation and spatial cognition. Previous in vitro work has found that estradiol triggers second messenger cascades, driving synaptic plasticity in the hippocampus. In particular, estradiol has been found to drive a pronounced proliferation of dendritic spines, the primary sites of excitatory synaptic connections.